The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2019
Filed:
Mar. 31, 2016
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Teresa Broering, Brookline, MA (US);
Colby Souders, North Weymouth, MA (US);
Gregory Babcock, Marlborough, MA (US);
Naomi Boatright, Quincy, MA (US);
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); G01N 33/68 (2006.01); C07K 16/40 (2006.01); C07H 1/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2863 (2013.01); C07H 1/00 (2013.01); C07K 16/40 (2013.01); G01N 33/689 (2013.01); C07K 2317/21 (2013.01); C07K 2317/92 (2013.01); G01N 2333/71 (2013.01); G01N 2800/368 (2013.01);
Abstract
Aspects of the present disclosure relate to binding agents (e.g., antibodies and antigen binding fragments) that bind soluble fms-like tyrosine kinase 1 (sFlt1) in an isoform specific manner. In some embodiments, immunological assay methods utilizing isoform-specific antibodies or antigen binding fragments that bind sFlt1 isoforms are provided for assessing biological samples obtained from pregnant subjects, e.g., for purposes of evaluating preeclampsia status in the subject.