The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2019
Filed:
Sep. 09, 2016
The General Hospital Corporation, Boston, MA (US);
University of Georgia Research Foundation, Athens, GA (US);
Galit Alter, Winchester, MA (US);
Robert Lance Wells, Athens, GA (US);
Wen-Han Yu, Brookline, MA (US);
THE GENERAL HOSPITAL CORPORATION, Boston, MA (US);
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, Athens, GA (US);
Abstract
Systems and methods have been developed to design and engineer glycan dynamics to improve immunogen antigenicity. These include systems for identify glycosylation sites that that impact binding of antibodies to the immunogen, and modifying the glycan profiles on these glycosylation sites to synthesize novel immunogens, antibodies and vaccines. Then, the machine learning algorithm may output data relating to the glycosylation sites that are determinant or likely impact the binding affinity of the variants to the one or more antibodies.