The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 24, 2019

Filed:

Jul. 29, 2016
Applicant:

Taiho Pharmaceutical Co., Ltd., Chiyoda-ku, JP;

Inventors:

Masayuki Nakamura, Tsukuba, JP;

Hiroyoshi Yamanaka, Moriya, JP;

Morihiro Mitsuya, Tsukuba, JP;

Takafumi Harada, Tsukuba, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 25/00 (2006.01); A61K 47/32 (2006.01); C07D 207/30 (2006.01); C07D 307/34 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/519 (2013.01); A61K 47/32 (2013.01); A61P 25/00 (2018.01); A61P 29/00 (2018.01); C07D 207/30 (2013.01); C07D 307/34 (2013.01);
Abstract

Provided are a novel compound or a salt thereof, and a pharmaceutical composition comprising the same, which selectively and strongly inhibit JAK3, exhibit an excellent activity for suppressing the growth of human peripheral blood monocytes and an excellent oral absorbability, and exhibits an activity of inhibiting IL-2-induced IFN-γ production in vivo. A compound represented by formula (I) [wherein X represents —CH═CH—, —NH—, a sulfur atom or an oxygen atom; and n represents an integer of 0 to 2], or a salt thereof.


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