The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 24, 2019
Filed:
Sep. 11, 2015
Applicant:
Medimmune Limited, Cambridge, Cambridgeshire, GB;
Inventors:
Philip Wilson Howard, Cambridge, GB;
Stephen John Gregson, Cambridge, GB;
Jean-Noel Levy, South San Francisco, CA (US);
Assignee:
Other;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 31/5517 (2006.01); C07D 487/04 (2006.01); C07K 5/062 (2006.01); C07K 5/065 (2006.01); C07K 5/078 (2006.01); A61K 47/68 (2017.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5517 (2013.01); A61K 47/6803 (2017.08); A61K 47/6855 (2017.08); C07D 487/04 (2013.01); C07K 5/06026 (2013.01); C07K 5/06052 (2013.01); C07K 5/06078 (2013.01); C07K 5/06165 (2013.01); C07K 16/3015 (2013.01); C07K 16/3046 (2013.01); Y02A 50/463 (2018.01);
Abstract
A conjugate comprising a PBD dimer linked from the tether joining the two PBD units, wherein the linker is of formula (A1):(Formula (A1)) wherein Ris selected from H and Calkyl; L is a linker connected to a cell binding agent; CBA is the cell binding agent; n is an integer selected in the range of 0 to 48; Q is: (Formula (Q)), where Qis such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue.