The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2019
Filed:
Mar. 04, 2016
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Hubert Kettenberger, Munich, DE;
Stefan Klostermann, Neuried, DE;
Florian Lipsmeier, Penzberg, DE;
Apollon Papadimitriou, Bichl, DE;
Jasmin Sydow-Andersen, Frederiksberg, DK;
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Abstract
Herein is reported a method for selecting or deselecting an antibody comprising a) determining for each Asp and Asn residue in an antibody Fv region the conformational flexibility of the C-atom using a homology model ensemble, b) determining for each Asp and Asn residue in an antibody Fv region the size of the amino acid residue C-terminal to the Asp or Asn residue, and c) selecting an antibody in which the C-atom is conformationally inflexible and/or the Asp or Asn has a big C-terminal amino acid residue, or deselecting an antibody in which the C-atom has a moderate to high conformational flexibility and/or the Asp or Asn has a small C-terminal amino acid residue.