The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2019
Filed:
Feb. 03, 2014
Applicant:
Eth Zurich, Zurich, CH;
Inventors:
Katrin Rossger, Zurich, CH;
Martin Fussenegger, Magenwil, CH;
Assignee:
ETH ZURICH, Zurich, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); A61K 35/12 (2015.01); C12N 15/09 (2006.01); A61K 38/10 (2006.01); A61K 38/18 (2006.01); A61K 38/22 (2006.01); A61K 38/26 (2006.01); A61K 38/27 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); A61K 9/0024 (2013.01); A61K 9/5036 (2013.01); A61K 35/12 (2013.01); A61K 38/10 (2013.01); A61K 38/105 (2013.01); A61K 38/1825 (2013.01); A61K 38/1866 (2013.01); A61K 38/22 (2013.01); A61K 38/2207 (2013.01); A61K 38/2264 (2013.01); A61K 38/26 (2013.01); A61K 38/27 (2013.01); A61K 47/6901 (2017.08); C12N 15/09 (2013.01); A01K 2207/12 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0393 (2013.01); C12N 2800/107 (2013.01); C12N 2800/60 (2013.01); C12N 2830/002 (2013.01);
Abstract
The invention relates to vectors and mammalian cells in a system useful for switching on or switching off gene expression in response to fatty acids, and a method of treating diet-induced obesity. In particular, a synthetic intracellular lipid-sensing receptor was constructed that constantly monitors blood fatty acid levels, processes diet-associated hyperlipidemia and coordinates reversible and adjustable expression of the anorectic peptide hormone pramlintide to reduce dietary intake, blood fat levels and body weight.