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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10415044 B1

PDFFull Text
Date of Patent:
Sep. 17, 2019

Filed:

Dec. 22, 2015

Adeno-associated virus vectors encoding modified g6pc and uses thereof

Applicant:

The U.s.a., As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventor:

Janice J. Chou, North Bethesda, MD (US);

Assignee:

The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Attorney:

Klarquist Sparkman, LLP

Primary Examiner:

Marcia S Noble

Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 15/66 (2006.01); A61K 38/00 (2006.01); C12N 9/16 (2006.01); A61K 38/47 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C12N 15/66 (2013.01); A61K 38/00 (2013.01); A61K 38/47 (2013.01); C12N 9/16 (2013.01); C12N 15/85 (2013.01); C12Y 301/03009 (2013.01); A61K 45/06 (2013.01); C12Y 302/00 (2013.01);
Abstract

Modified G6PC (glucose-6-phosphatase, catalytic subunit) nucleic acids and glucose-6-phosphatase-α (G6Pase-α) enzymes with increased phosphohydrolase activity are described. Also described are vectors, such as adeno-associated virus (AAV) vectors, and recombinant AAV expressing modified G6Pase-α. The disclosed AAV vectors and rAAV can be used for gene therapy applications in the treatment of glycogen storage disease, particularly glycogen storage disease type Ia (GSD-Ia), and complications thereof.

Find Patent Forward Citations

Chou, Janice. (2019). Adeno-associated virus vectors encoding modified g6pc and uses thereof (U.S. Patent No. 10415044). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10415044

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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