The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2019
Filed:
Apr. 04, 2016
Applicant:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Inventors:
Shuling Guo, Carlsbad, CA (US);
Mariam Aghajan, San Diego, CA (US);
Eric E. Swayze, Encinitas, CA (US);
Assignee:
Ionis Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 47/54 (2017.01); A61P 7/06 (2006.01); A61P 7/00 (2006.01); C07H 21/00 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1137 (2013.01); A61K 47/549 (2017.08); A61P 7/00 (2018.01); A61P 7/06 (2018.01); C07H 21/00 (2013.01); C12N 15/113 (2013.01); C12N 15/1138 (2013.01); C12Y 304/21109 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/334 (2013.01); C12N 2310/341 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3525 (2013.01); C12N 2310/3527 (2013.01);
Abstract
Disclosed herein are compositions and compounds comprising modified oligonucleotides for modulating TMPRSS6 and modulating an iron accumulation disease, disorder and/or condition in an individual in need thereof. Iron accumulation diseases in an individual such as polycythemia, hemochromatosis or β-thalassemia can be treated, ameliorated, delayed or prevented with the administration of antisense compounds targeted to TMPRSS6.