The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2019
Filed:
Nov. 23, 2016
Fresenius Kabi Ipsum S.r.l., Cassina de' Pecchi (Milan), IT;
Walter Cabri, Milan, IT;
Antonio Ricci, Pescara, IT;
Jacopo Zanon, Venice, IT;
Saswata Lahiri, Ghaziabad, IN;
Govind Singh, Ghaziabad, IN;
Dominik Heckmann, Friedberg, DE;
FRESENIUS KABI IPSUM S.R.L., Cassina de' Pecchi (Milan), IT;
Abstract
The present application provides an improved process for the preparation of sugammadex which comprises the halogenation of γ-cyclodextrin in a suitable organic solvent to give 6-per-deoxy-6-per-halo-γ-cyclodextrin, wherein halo is bromo or chloro, reacting the halogenated γ-cyclodextrin with 3-mercaptopropionic acid in the presence of alkoxide base to obtain sugammadex of formula I. This application also provides isolation of 6-per-deoxy-6-per-chloro-γ-cyclodextrin as a crystalline compound and its use for the preparation of sugammadex of formula (I).