The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2019
Filed:
Jul. 02, 2015
Applicants:
City of Hope, Duarte, CA (US);
Thomas Jefferson University, Philadelphia, PA (US);
Inventors:
John C. Williams, Monrovia, CA (US);
Ulrich Rodeck, Philadelphia, PA (US);
Kurt Jenkins, Duarte, CA (US);
Assignees:
City of Hope, Duarte, CA (US);
Thomas Jefferson University, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/82 (2006.01); C07K 16/46 (2006.01); C07K 14/705 (2006.01); C12N 9/64 (2006.01); C07K 14/435 (2006.01); C07K 19/00 (2006.01); C07K 16/28 (2006.01); C07K 14/47 (2006.01); C07K 14/71 (2006.01);
U.S. Cl.
CPC ...
C07K 14/82 (2013.01); C07K 14/47 (2013.01); C07K 14/70596 (2013.01); C07K 14/71 (2013.01); C07K 16/2818 (2013.01); C12N 9/6491 (2013.01); C07K 2317/35 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2318/20 (2013.01); C07K 2319/30 (2013.01); C07K 2319/50 (2013.01);
Abstract
Provided herein are recombinant masking proteins and recombinant ligand proteins useful in treating cancer, neurodegenerative disease, and cardiovascular disease. The recombinant masking proteins provided herein may, inter alia, be used as non-covalent masks of antagonists of, for example, cellular growth factors (e.g., TNF) or cell surface proteins (e.g., CTLA-4).