The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2019
Filed:
Aug. 03, 2013
The Regents of the University of Colorado, a Body Corporate, Denver, CO (US);
Marvin H. Caruthers, Boulder, CO (US);
Subhadeep Roy, Boulder, CO (US);
Marvin H. Caruthers, Boulder, CO (US);
Subhadeep Roy, Boulder, CO (US);
The Regents of the University of Colorado, Denver, CO (US);
Abstract
The present invention provides nucleosides an exocyclic amine-protected nucleoside of the formula: A-B where A is a 5'-protected ribose, 5′-protected-2-deoxyribose, 5′-protected-3′-phosphoramidite ribose, or 5′-protected-3′-phosphoramidite-2-deoxyribose moiety; and B is a nucleobase having an exocyclic amine group that is protected with di-tert-butylisobutylsilyl ('BIBS') protecting group. Use of BIBS protecting group provides an exocyclic amine-protected nucleoside that is stable to a wide variety of reaction conditions associated with oligonucleotide synthesis. The present invention also provides, oligonucleotides comprising the same, and methods for producing the same.