The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 17, 2019

Filed:

Jan. 19, 2018
Applicant:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Esteban Masuda, Menlo Park, CA (US);

Rajinder Singh, Belmont, CA (US);

Vanessa Taylor, San Francisco, CA (US);

Donald G. Payan, Hillsborough, CA (US);

Assignee:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/675 (2006.01); C07D 413/12 (2006.01); C07F 9/653 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 413/12 (2013.01); A61K 31/506 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07F 9/65324 (2013.01); Y10T 436/141111 (2015.01);
Abstract

Compounds and embodiments of a method for treating and/or preventing autoimmune diseases are disclosed. The method includes administering to a subject having an autoimmune disease, such as an inflammatory bowel disease, a therapeutically effective amount of a compound according to formula I wherein X and Y independently are O or NR; each Ris independently H or C-Calkyl; ring A is aryl; each Rindependently is H, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two Rgroups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; Rand Rindependently are H or C-Calkyl; and Ris halo, cyano, or C-Calkyl.


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