The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 17, 2019

Filed:

Jan. 18, 2016
Applicant:

Zhejiang Hisun Pharmaceutical Co., Ltd., Zhejiang, CN;

Inventors:

Mingxing Yin, Zhejiang, CN;

Dongdong Wu, Zhejiang, CN;

Weijiang Wen, Zhejiang, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 315/00 (2006.01); C07H 1/00 (2006.01); C07H 17/00 (2006.01); C07H 17/08 (2006.01);
U.S. Cl.
CPC ...
C07D 315/00 (2013.01); C07H 1/00 (2013.01); C07H 17/00 (2013.01); C07H 17/08 (2013.01);
Abstract

A method and an intermediate for preparing a tulathromycin. The method includes the following step: in an organic solvent, subjecting a compound represented by formula (II) and an n-propylamine to a ring-opening addition shown below to obtain a tulathromycin represented by formula (I), wherein the organic solvent is a 1,2-propandiol. Tulathromycin obtained using the method has a high purity, with an HPLC purity being 95% and above, and up to 99% and above, satisfying a required purity for preparing a tulathromycin as a pharmaceutical formulation. The method has a high yield, is simple to operate, and is more suitable for industrial production.


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