The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2019
Filed:
Nov. 12, 2015
Applicant:
Ucl Business Plc, London, GB;
Inventors:
Assignee:
UCL Business PLC, London, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 15/63 (2006.01); C07H 21/04 (2006.01); A61K 38/48 (2006.01); C12N 9/64 (2006.01); A61P 7/04 (2006.01); A61K 38/27 (2006.01); C12N 9/50 (2006.01); C12N 15/113 (2010.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4846 (2013.01); A61K 38/27 (2013.01); A61P 7/04 (2018.01); C12N 9/50 (2013.01); C12N 9/644 (2013.01); C12N 15/113 (2013.01); C12N 15/62 (2013.01); C12N 15/85 (2013.01); C12Y 304/21022 (2013.01); C07H 21/04 (2013.01); C12N 15/79 (2013.01);
Abstract
The invention relates to a new, more potent, coagulation factor IX (FIX) expression cassette for gene therapy of haemophilia B (HB). Disclosed is a vector for expressing factor IX protein, the vector comprising a promoter, a nucleotide sequence encoding for a functional factor IX protein and an intron sequence, wherein the intron sequence is positioned between exon 1 and exon 2 of the nucleotide sequence encoding for a functional factor IX protein, and wherein the intron sequence has at least 80% identity to the sequence of SEQ ID NO. 1 as disclosed herein.