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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10413598 B1

PDFFull Text
Date of Patent:
Sep. 17, 2019

Filed:

Nov. 12, 2015

Factor ix gene therapy

Applicant:

Ucl Business Plc, London, GB;

Inventors:

Amit Nathwani, London, GB;

Jenny Mcintosh, London, GB;

Nishil Patel, London, GB;

Assignee:

UCL Business PLC, London, GB;

Attorney:

Patent Law Works LLP

Primary Examiner:

Shin Lin Chen

Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 15/63 (2006.01); C07H 21/04 (2006.01); A61K 38/48 (2006.01); C12N 9/64 (2006.01); A61P 7/04 (2006.01); A61K 38/27 (2006.01); C12N 9/50 (2006.01); C12N 15/113 (2010.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4846 (2013.01); A61K 38/27 (2013.01); A61P 7/04 (2018.01); C12N 9/50 (2013.01); C12N 9/644 (2013.01); C12N 15/113 (2013.01); C12N 15/62 (2013.01); C12N 15/85 (2013.01); C12Y 304/21022 (2013.01); C07H 21/04 (2013.01); C12N 15/79 (2013.01);
Abstract

The invention relates to a new, more potent, coagulation factor IX (FIX) expression cassette for gene therapy of haemophilia B (HB). Disclosed is a vector for expressing factor IX protein, the vector comprising a promoter, a nucleotide sequence encoding for a functional factor IX protein and an intron sequence, wherein the intron sequence is positioned between exon 1 and exon 2 of the nucleotide sequence encoding for a functional factor IX protein, and wherein the intron sequence has at least 80% identity to the sequence of SEQ ID NO. 1 as disclosed herein.

Find Patent Forward Citations

Nathwani, Amit. (2019). Factor ix gene therapy (U.S. Patent No. 10413598). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10413598

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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