The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 17, 2019
Filed:
Sep. 01, 2016
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Chia-Jen Siao, New York, NY (US);
Hoi-Ching Lee, Dumont, NJ (US);
Zhe Li, Fort Lee, NJ (US);
Ka-Man Venus Lai, Tarrytown, NY (US);
Gavin Thurston, Briarcliff Manor, NY (US);
Assignee:
REGENERON PHARMACEUTICALS, INC., Tarrrytown, NY (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 5/0735 (2010.01); C07K 7/08 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0275 (2013.01); A01K 67/0271 (2013.01); C07K 7/08 (2013.01); C12N 5/0606 (2013.01); A01K 2207/12 (2013.01); A01K 2217/05 (2013.01); A01K 2217/052 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); A01K 2267/0393 (2013.01); C07K 2319/50 (2013.01); C07K 2319/61 (2013.01); C12N 2015/8572 (2013.01); C12N 2830/008 (2013.01); C12N 2830/36 (2013.01);
Abstract
This disclosure provides a rodent model of prostate cancer. The rodents disclosed herein comprise a transgene that provides prostate-specific expression of an oncogenic protein (e.g, an SV40 tumor antigen) under the control of 5' and 3′ regulatory regions of a mouse probasin gene. The rodents develop progressive forms of prostate tumor that resemble the development of human prostate cancer.