The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2019
Filed:
Sep. 18, 2015
Applicants:
Inserm, Paris, FR;
Université Paris Diderot—paris 7, Paris, FR;
Inventors:
Assignees:
INSERM (Institut National de la Santé et de la Recherche Médicale), Paris, FR;
Université Paris Didrerot—Paris 7, Paris, FR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); A61K 39/0005 (2013.01); A61K 39/3955 (2013.01); A61K 2039/505 (2013.01); A61K 2039/575 (2013.01); C07K 16/2863 (2013.01); C07K 2317/24 (2013.01); C07K 2317/30 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
The present invention relates to an anti-Notch 3 antibody therapy useful for treatment of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. In particular, the invention relates to an anti-Notch3 antibody or a fragment thereof having a 2 fold, 4 fold or 10 fold higher affinity to Notch 3 than to Notch 1 or Notch 2 for use in therapy.