The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2019
Filed:
Mar. 11, 2015
Applicant:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Inventors:
Allison D. Ortigosa, Harrisonburg, VA (US);
Michael P. Coleman, Louisville, CO (US);
Shibu T. George, Thornton, CO (US);
Michael A. Rauscher, Garwood, NJ (US);
Mark C. Sleevi, Longmont, CO (US);
Kartoa Chow, San Francisco, CA (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/62 (2006.01); C07K 1/18 (2006.01); C07K 1/20 (2006.01);
U.S. Cl.
CPC ...
C07K 14/62 (2013.01); C07K 1/18 (2013.01); C07K 1/20 (2013.01);
Abstract
A process is described for purifying insulin and insulin analogs that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed in the presence of a water miscible organic modifier and at an elevated temperature followed by reverse phase chromatography performed in the presence of a water miscible organic modifier and at an elevated temperature.