The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2019
Filed:
Jul. 25, 2016
Applicant:
Alkermes, Inc., Waltham, MA (US);
Inventor:
Juan Alvarez, Chelmsford, MA (US);
Assignee:
Alkermes Pharma Ireland Limited, Dublin, IE;
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); C07K 14/705 (2006.01); C07K 14/55 (2006.01); C07K 14/47 (2006.01); C07K 14/545 (2006.01); C07K 14/54 (2006.01); C07K 14/715 (2006.01); C07K 14/50 (2006.01); C07K 14/71 (2006.01); C07K 14/575 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/55 (2013.01); C07K 14/4713 (2013.01); C07K 14/4727 (2013.01); C07K 14/50 (2013.01); C07K 14/54 (2013.01); C07K 14/545 (2013.01); C07K 14/5412 (2013.01); C07K 14/5443 (2013.01); C07K 14/57563 (2013.01); C07K 14/70503 (2013.01); C07K 14/71 (2013.01); C07K 14/7155 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01); C07K 2319/74 (2013.01); C07K 2319/91 (2013.01);
Abstract
The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity, increased agonist activity (super agonist), antagonist activity, increased accessibility, increased flexibility of the active site, increased stability, broader and/or changed substrate specificity, and combinations thereof.