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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10407435 B1

PDFFull Text
Expired
Date of Patent:
Sep. 10, 2019

Filed:

Oct. 29, 2015

Diheteroaryl histone deacetylase inhibitors and their use in therapy

Applicant:

Karus Therapeutics Limited, Oxfordshire, GB;

Inventors:

Stephen Joseph Shuttleworth, Oxfordshire, GB;

Alexander Richard Liam Cecil, Oxfordshire, GB;

Somhairle MacCormick, Oxfordshire, GB;

William John Nodes, Oxfordshire, GB;

Cyrille Davy Tomassi, Oxfordshire, GB;

Assignee:

Karus Therapeutics Limited, Oxfordshire, GB;

Attorney:

Goodwin Procter LLP

Primary Examiner:

Jeffrey H Murray

Int. Cl.
CPC ...
A61K 31/497 (2006.01); C07D 491/048 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 241/20 (2006.01); C07D 417/12 (2006.01); C07D 487/04 (2006.01); A61K 31/4985 (2006.01); A61K 31/501 (2006.01); A61K 31/5025 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 491/048 (2013.01); A61K 31/497 (2013.01); A61K 31/4985 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5025 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 241/20 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01);
Abstract

The present invention is a compound having the following formula: (Formula (I)) or a pharmaceutically acceptable salt thereof, wherein e.g. X is C or N; n is 1 to 10; each L is independently a 5- to 12-membered heteroaryl containing at least two nitrogen atoms; and W is a zinc-binding group. The compounds are useful as histone deacetylase (HDAC) inhibitors.

Find Patent Forward Citations

Shuttleworth, Stephen. (2019). Diheteroaryl histone deacetylase inhibitors and their use in therapy (U.S. Patent No. 10407435). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10407435

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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