IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10407408 B1

PDFFull Text
Date of Patent:
Sep. 10, 2019

Filed:

Jul. 08, 2016

Imide derivatives and use thereof as medicine

Applicant:

Mitsubishi Tanabe Pharma Corporation, Osaka-shi, Osaka, JP;

Inventors:

Seigo Ishibuchi, Osaka, JP;

Kunio Saruta, Osaka, JP;

Maiko Hamada, Osaka, JP;

Nobuatsu Matoba, Osaka, JP;

Tetsuji Matsudaira, Osaka, JP;

Maki Seki, Osaka, JP;

Akiko Tarao, Osaka, JP;

Takashi Honjo, Osaka, JP;

Shingo Ogata, Osaka, JP;

Atsushi Kawata, Osaka, JP;

Kenji Morokuma, Osaka, JP;

Naoto Fujie, Osaka, JP;

Yukio Aoyama, Osaka, JP;

Assignee:

MITSUBISHI TANABE PHARMA CORPORATION, Osaka, JP;

Attorney:

Leydig, Voit & Mayer, Ltd.

Primary Examiner:

Charanjit Aulakh

Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 31/496 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); A61K 31/4178 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/497 (2006.01); A61K 31/501 (2006.01); C07D 233/78 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 403/10 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01); A61P 19/02 (2006.01); A61P 1/00 (2006.01); A61P 25/00 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/4178 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61P 1/00 (2018.01); A61P 19/02 (2018.01); A61P 25/00 (2018.01); C07D 233/78 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 403/10 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 498/04 (2013.01); C07D 513/04 (2013.01);
Abstract

Provided is a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2. The present invention relates to a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION. The compound has a selective MMP-9 production suppressive action, and is useful as a drug for the prophylaxis and/or treatment of autoimmune diseases such as rheumatoid arthritis and the like, inflammatory bowel diseases (ulcerative colitis, Crohn's disease) or osteoarthritis.

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