The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 10, 2019

Filed:

May. 19, 2016
Applicant:

Glaxosmithkline Intellectual Property Development Limited, Brentford, GB;

Inventors:

Dominique Amans, Singapore, SG;

Stephen John Atkinson, Stevenage, GB;

Michael David Barker, Stevenage, GB;

Matthew Campbell, Stevenage, GB;

Hawa Diallo, Stevenage, GB;

Clement Douault, Stevenage, GB;

Neil Stuart Garton, Stevenage, GB;

John Liddle, Stevenage, GB;

Jessica Fanny Renaux, Middlesex, GB;

Robert John Sheppard, Stevenage, GB;

Ann Louise Walker, Stevenage, GB;

Christopher Roland Wellaway, Stevenage, GB;

David Matthew Wilson, Madrid, ES;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 403/14 (2006.01); C07D 498/06 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 498/04 (2013.01); C07D 498/06 (2013.01);
Abstract

Compounds of formula (I): wherein X, Y, Rand R-Rare as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.


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