The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2019
Filed:
Jul. 28, 2014
Zonhon Biopharma Institute Inc., Changzhou, Jiangsu, CN;
Gensun Institute of Biomedicine Co., Ltd., Wujin Changzhou, Jiangsu, CN;
Bruce Yong Ma, Jiangsu, CN;
Jun Wang, Jiangsu, CN;
Dinglong Wu, Jiangsu, CN;
Chunlin Xu, Jiangsu, CN;
Yaofang Wang, Jiangsu, CN;
ZONHON BIOPHARMA INSTITUTE INC., Changzhou, CN;
GENSUN INSTITUTE OF BIOMEDICINE CO., LTD., Changzhou, CN;
Abstract
Methods for use of a multi-arm polyethylene glycol (PEG) modifier in modification of asparaginase. The described multi-arm PEG modifier enhances the subunit interaction of a multimeric protein to maintain the multimeric protein in a polymerized form, thereby improving the stability of the multimeric protein, maintaining the bioactivity of the multimeric protein, and reducing the probability of exposure of the antigen binding site after depolymerization of the subunits, so as to reduce the immunogenicity.