The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 10, 2019

Filed:

Jun. 09, 2017
Applicants:

National Research Council of Canada, Ottawa, CA;

National Health Research Institutes, Zhunan, CN;

Inventors:

Chih-Hsiang Leng, Taipei, CN;

Wangxue Chen, Ottawa, CA;

Pele Chong, Zhunan, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 1/00 (2006.01); A61K 39/09 (2006.01); C07K 16/12 (2006.01); C07K 7/08 (2006.01); C07K 14/315 (2006.01); C12P 21/02 (2006.01); C12N 15/63 (2006.01); C12N 15/70 (2006.01); C07K 19/00 (2006.01); A61P 31/04 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/092 (2013.01); A61P 31/04 (2018.01); C07K 7/08 (2013.01); C07K 14/315 (2013.01); C07K 14/3156 (2013.01); C07K 16/12 (2013.01); C07K 19/00 (2013.01); C12N 15/63 (2013.01); C12N 15/70 (2013.01); C12P 21/02 (2013.01); A61K 2039/6018 (2013.01); C07K 2319/00 (2013.01); C07K 2319/21 (2013.01);
Abstract

There are provided compositions and methods for prevention or treatment of(SP)-associated diseases. More specifically, there are provided recombinant lipidated fusion proteins comprising pneumococcal surface antigen A (PsaA), the recombinant lipidated fusion proteins comprising, from N-terminus to C-terminus, the N-terminal native lipid signal peptide of PsaA and the C-terminal structural gene for PsaA. Methods of inducing broad spectrum mucosal immunity against SP comprising administering a vaccine comprising recombinant lipidated fusion proteins are also described.


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