The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 10, 2019

Filed:

Sep. 08, 2015
Applicant:

Virginia Tech Intellectual Properties, Inc., Blacksburg, VA (US);

Inventors:

Sriranganathan Nammalwar, Blacksburg, VA (US);

Hamzeh Al Qublan, Blacksburg, VA (US);

Garrett Smith, Blacksburg, VA (US);

Stephen Boyle, Blacksburg, VA (US);

Gerhardt Schurig, Blacksburg, VA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/04 (2006.01); A61K 45/06 (2006.01); A61K 35/74 (2015.01); C07K 14/35 (2006.01); C12N 1/20 (2006.01); C12N 15/74 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/04 (2013.01); A61K 35/74 (2013.01); A61K 45/06 (2013.01); C07K 14/35 (2013.01); C12N 1/20 (2013.01); C12N 15/74 (2013.01); A61K 2039/523 (2013.01); A61K 2039/552 (2013.01); A61K 2039/70 (2013.01);
Abstract

Provided herein is a multivalentvaccine expressing at least one heterologousantigen. The vaccines described herein serve as an environmentally safe bivalent vaccine for protection againstandinfections simultaneously. In particular, a multivalent vaccine comprising astrain transformed with a vector that expresses at least oneantigen, where theantigen(s) is codon optimized for thestrain is provided. In some aspects, thestrain isstrain RB51 leuB and theantigen is one or more of Ag85B, Rv2660c, and ESAT6.


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