Piperidine-2, 6-dione derivatives and their use as tumor necrosis factor inhibitors

Abstract

This invention is directed to derivatives of piperidine-2,6-dione, or their organic or inorganic salts thereof, a methods of synthesis of these derivatives, and their application as active pharmaceutical ingredient as inhibitors of TNFα releasing in cells, the derivative of piperidine-2,6-dione being of the general formula (I): wherein n represents 1, 2, 3, 4, 5 or 6; Rrepresents from one to four of the same or different substituents selected from F, Cl, Br, Calkyl, OH, OCalkyl, NO, NHC(O)Calkyl, NH, NH(Calkyl), N(Calkyl); Rrepresents OR, NRR, N(R)COR, OCR; Rand Rrepresent independently and at each occurrence H or Calkyl; Rrepresents CHRNRR, CHRNRC(O)CHRNRR, a heterocycle W or CHRNRC(O)W; R, R, Rrepresent independently and at each occurrence H, or Calkyl; Rand Rrepresent independently and at each occurrence H, Calkyl, or Rand Rtaken together represent 1,3-propylene, 1,4-butylene, 1,5-pentylene, or 1,6-hexylene; W represents four-membered, five-membered, six-membered, seven-membered, or eight-membered saturated or unsaturated heterocycle.