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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10406125 B1

PDFFull Text
Date of Patent:
Sep. 10, 2019

Filed:

Oct. 14, 2016

Combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof and a compound able to increase the h2o2 level in cancer cells of a subject

Applicant:

Advanced Biodesign, Saint-Priest, FR;

Inventors:

Ismail Ceylan, Saint-Priest, FR;

Gerry Quash, Saint-Priest, FR;

Mileidys Perez-Alea, Saint-Priest, FR;

Guillaume Martin, Saint-Priest, FR;

Assignee:

ADVANCED BIODESIGN, Saint Priest, FR;

Attorney:

Troutman Sanders LLP

Primary Examiner:

Brian J Davis

Int. Cl.
CPC ...
A61K 31/145 (2006.01); A61K 45/06 (2006.01); A61K 31/131 (2006.01); A61K 31/136 (2006.01); A61K 31/137 (2006.01); A61K 31/4453 (2006.01); A61K 31/498 (2006.01); A61K 31/5375 (2006.01); A61K 31/704 (2006.01); A61K 33/24 (2019.01); A61K 33/36 (2006.01); G01N 33/574 (2006.01); G01N 33/68 (2006.01); G01N 33/84 (2006.01); A61P 35/02 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
A61K 31/145 (2013.01); A61K 31/131 (2013.01); A61K 31/136 (2013.01); A61K 31/137 (2013.01); A61K 31/4453 (2013.01); A61K 31/498 (2013.01); A61K 31/5375 (2013.01); A61K 31/704 (2013.01); A61K 33/24 (2013.01); A61K 33/36 (2013.01); A61K 45/06 (2013.01); A61P 35/02 (2018.01); G01N 21/64 (2013.01); G01N 33/57496 (2013.01); G01N 33/68 (2013.01); G01N 33/84 (2013.01); A61K 2300/00 (2013.01); G01N 2440/00 (2013.01);
Abstract

The present invention relates to a combination comprising an aminothiolester compound or a pharmaceutically acceptable salt thereof, in particular the S-methyl 4-(dimethylamino)-4-methylpent-2-ynethioate or a pharmaceutically acceptable salt thereof, and more particularly the 4-(Dimethylamino)-4-methyl-2-pentynethioic acid S-methyl ester fumarate, and a compound able to increase HOlevel in cancer cells of a subject, in particular for use for the treatment of cancer in a subject, wherein cancer cells of said subject do not overproduce HOin comparison to a control value and have a level of GSH below 5 nmol for 25000 cells.

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