The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2019
Filed:
Nov. 03, 2017
Applicant:
University of Cincinnati, Cincinnati, OH (US);
Inventors:
Jianjun Chen, Cincinnati, OH (US);
Xi Jiang, Cincinnati, OH (US);
Assignee:
University of Cincinnati, Cincinnati, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12N 15/11 (2006.01); A61K 48/00 (2006.01); C12N 15/113 (2010.01); A61P 35/02 (2006.01); A61K 47/59 (2017.01); A61K 47/64 (2017.01); A61K 31/713 (2006.01); A61K 31/203 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1135 (2013.01); A61K 9/0019 (2013.01); A61K 31/203 (2013.01); A61K 31/713 (2013.01); A61K 47/595 (2017.08); A61K 47/64 (2017.08); A61P 35/02 (2018.01); C12N 15/113 (2013.01); C12N 2310/141 (2013.01); C12N 2310/321 (2013.01); C12N 2320/31 (2013.01); C12N 2320/32 (2013.01);
Abstract
Compositions and methods for treating acute myeloid leukemia (AML) based on upregulating expression of microRNA-22 (miR-22), and a nanoparticle delivery system that utilizes FLT3-functionalized polyamidoamine (PAMAM) dendromirs for targeted delivery of miR-22 and/or agents that upregulate expression of miR-22 to AML cells.