The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2019
Filed:
Mar. 13, 2017
Applicants:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Brian Bettencourt, Groton, MA (US);
Kevin Fitzgerald, Brookline, MA (US);
William Querbes, Cambridge, MA (US);
Robert J. Desnick, New York, NY (US);
Makiko Yasuda, New York, NY (US);
Assignees:
ALNYLAM PHARMACEUTICALS, INC., Cambridge, MA (US);
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/713 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); C12N 15/1137 (2013.01); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/343 (2013.01); C12N 2310/344 (2013.01); C12N 2310/351 (2013.01); C12N 2310/3521 (2013.01); C12N 2310/3533 (2013.01); C12N 2310/50 (2013.01); C12N 2310/533 (2013.01); C12N 2320/30 (2013.01); C12Y 203/01037 (2013.01);
Abstract
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.