The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2019
Filed:
Mar. 17, 2015
The University of Manitoba, Winnipeg, CA;
The Hospital for Sick Children, Toronto, CA;
Don Mahuran, Toronto, CA;
Brian Mark, Winnipeg, CA;
The University of Manitoba, Winnipeg, MB, unknown;
The Hospital for Sick Children, Toronto, ON, unknown;
Abstract
Embodiments herein include variants of β-hexosaminidase that are useful for hydrolyzing GM2 ganglioside, polynucleotides encoding the same, and related methods. In various embodiments, a variant β-hexosaminidase subunit is included wherein the variant β-hexosaminidase subunit forms a homodimer under physiological conditions and wherein the variant β-hexosaminidase subunit associates with Gactivator protein to hydrolyze Gganglioside. In some embodiments, an isolated or recombinant polynucleotide encoding such a variant β-hexosaminidase subunit is included. In some embodiments, a method of treating a subject exhibiting an abnormal cellular accumulation of GM2 ganglioside is included wherein the method includes administering a composition including a protein variant of β-hexosaminidase or a polynucleotide encoding the same. Other embodiments are included herein.