The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2019
Filed:
Nov. 22, 2017
Medimmune, Llc, Gaithersburg, MD (US);
University of Helsinki, Helsinki, FI;
Kari Alitalo, Helsinki, FI;
Simo Syrjala, Helsinki, FI;
Karl Lemstrom, Helsinki, FI;
Ching Ching Leow, Gaithersburg, MD (US);
Ronald Herbst, Gaithersburg, MD (US);
Jane Connor, Gaithersburg, MD (US);
MedImmune, LLC, Gaithersburg, MD (US);
University of Helsinki, Helsinki, FI;
Abstract
The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.