The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2019
Filed:
Sep. 04, 2014
Tianjin Medical University, Tianjin, CN;
Shumei Xu, Tianjin, CN;
Tianjin Medical University, Tianjin, CN;
Abstract
Provided in the present invention are a β-sheet breaker peptide used for preventing and/or treating Alzheimer's disease, and the use thereof for preventing and/or treating Alzheimer's disease. The amino acid sequence of the β-sheet breaker peptide is His-Lys-Gln-Leu-Pro-Phe-Tyr-Glu-Glu-Asp (SEQ ID NO:1). The polypeptide can specially bind to a β-amyloid protein monomer (Aβ), and prevent the formation of β-sheet, thereby inhibiting Aβ peptide aggregation, reducing the formation of Aβ soluble oligomer, Aβ fiber and senile plaques in the brain, and accelerating the degradation and removal of Aβ peptide.