The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 03, 2019

Filed:

Feb. 05, 2016
Applicants:

University of Washington, Seattle, WA (US);

Fred Hutchinson Cancer Research Center, Seattle, WA (US);

Oricula Therapeutics Llc, Seattle, WA (US);

Inventors:

Julian Simon, Seattle, WA (US);

Graham Johnson, Sanbornton, NH (US);

Edwin W. Rubel, Seattle, WA (US);

David W. Raible, Seattle, WA (US);

Mario D. Gonzalez, Winchester, MA (US);

Peter C. Meltzer, Lexington, MA (US);

Weishi Miao, Winchester, MA (US);

Assignees:

University of Washington, Seattle, WA (US);

Oricula Therapeutics LLC, Seattle, WA (US);

Fred Hutchinson Cancer Research Center, Seattle, WA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/439 (2006.01); C07D 495/18 (2006.01); A61K 31/7036 (2006.01); A61P 27/00 (2006.01);
U.S. Cl.
CPC ...
C07D 495/18 (2013.01); A61K 31/439 (2013.01); A61K 31/7036 (2013.01); A61P 27/00 (2018.01); Y02A 50/411 (2018.01);
Abstract

Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.


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