The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 03, 2019

Filed:

Mar. 28, 2017
Applicant:

Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, CN;

Inventors:

Jinqing Zhong, Taizhou, CN;

Xuyang Zhao, Chengdu, CN;

Hua Bai, Taizhou, CN;

Yongxiang Gong, Taizhou, CN;

Xinlong Zhang, Taizhou, CN;

Qifeng Zhu, Taizhou, CN;

Weiwei Liu, Taizhou, CN;

Ya Zhou, Taizhou, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/056 (2006.01); C07D 491/113 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
C07D 491/056 (2013.01); C07D 491/113 (2013.01); A61P 25/28 (2018.01); Y02P 20/55 (2015.11);
Abstract

Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production.


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