The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 03, 2019

Filed:

Aug. 17, 2015
Applicant:

Ono Pharmaceutical Co., Ltd., Osaka-shi, Osaka, JP;

Inventors:

Jun Takeuchi, Osaka, JP;

Satoshi Itadani, Osaka, JP;

Masahiro Ikura, Osaka, JP;

Masato Higashino, Osaka, JP;

Hideomi Kijima, Osaka, JP;

Shizuka Ono, Osaka, JP;

Tetsuya Yasuhiro, Osaka, JP;

Takeshi Nagaura, Osaka, JP;

Assignee:

ONO PHARMACEUTICAL CO., LTD., Osaka-Shi, Osaka, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 401/14 (2006.01); A61K 45/00 (2006.01); A61K 31/506 (2006.01); C07C 309/04 (2006.01); A61K 45/06 (2006.01); C07C 309/29 (2006.01); C07C 309/30 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 31/506 (2013.01); A61K 45/00 (2013.01); A61K 45/06 (2013.01); C07C 309/04 (2013.01); C07C 309/29 (2013.01); C07C 309/30 (2013.01); C07D 401/14 (2013.01); C07B 2200/13 (2013.01);
Abstract

In order to provide a prophylactic and/or therapeutic agent for Trk-related diseases, the present invention provides a compound which has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and in addition thereto, is excellent in solubility and absorbability against free bases. The compound of the present invention has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and is excellent in solubility and absorbability against free bases, and is therefore useful as a prophylactic and/or therapeutic agent for Trk-related diseases.


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