IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10399932 B1

PDFFull Text
Date of Patent:
Sep. 03, 2019

Filed:

Apr. 01, 2016

Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer

Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

James Aaron Balog, Lambertville, NJ (US);

Emily Charlotte Cherney, Newtown, PA (US);

Jay A. Markwalder, Lahaska, PA (US);

Steven P. Seitz, Swarthmore, PA (US);

Weifang Shan, Princeton, NJ (US);

David K. Williams, Delran, NJ (US);

Audris Huang, New Hope, PA (US);

Susheel Jethanand Nara, Bangalore, IN;

Saumya Roy, Bangalore, IN;

Soodamani Thangavel, Krishnagiri, IN;

Ramesh Kumar Sistla, Bangalore, IN;

Srinivas Cheruku, Bangalore, IN;

Srinivasan Thangathirupathy, Hosur, IN;

Yadagiri Kanyaboina, Bangalore, IN;

Nagalakshmi Pulicharla, Bangalore, IN;

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:

Laura L Stockton

Int. Cl.
CPC ...
C07D 309/14 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 335/02 (2006.01); C07D 211/10 (2006.01); C07D 265/30 (2006.01); C07D 409/12 (2006.01); C07C 275/40 (2006.01); A61K 31/17 (2006.01); A61K 31/196 (2006.01); A61K 31/277 (2006.01); A61K 31/351 (2006.01); A61K 31/382 (2006.01); A61K 31/397 (2006.01); A61K 31/428 (2006.01); A61K 31/437 (2006.01); A61K 31/445 (2006.01); A61K 31/501 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61K 31/538 (2006.01); A61K 39/395 (2006.01); C07C 229/42 (2006.01); C07C 255/58 (2006.01); C07D 205/04 (2006.01); C07D 211/14 (2006.01); C07D 239/47 (2006.01); C07D 265/36 (2006.01); C07D 277/64 (2006.01); C07D 295/155 (2006.01); C07D 309/04 (2006.01); C07D 401/12 (2006.01); C07D 405/14 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 407/12 (2006.01); C07D 487/08 (2006.01); C07D 207/08 (2006.01); C07D 211/08 (2006.01); C07D 307/22 (2006.01); C07C 255/57 (2006.01); C07C 235/38 (2006.01); C07C 235/56 (2006.01); C07C 233/81 (2006.01); C07C 275/42 (2006.01); C07D 207/12 (2006.01); C07D 239/34 (2006.01); C07D 317/46 (2006.01); C07D 413/14 (2006.01); C07D 471/08 (2006.01); C07C 275/30 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07C 275/40 (2013.01); A61K 31/17 (2013.01); A61K 31/196 (2013.01); A61K 31/277 (2013.01); A61K 31/351 (2013.01); A61K 31/382 (2013.01); A61K 31/397 (2013.01); A61K 31/428 (2013.01); A61K 31/437 (2013.01); A61K 31/445 (2013.01); A61K 31/501 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/538 (2013.01); A61K 31/5375 (2013.01); A61K 31/5377 (2013.01); A61K 39/3955 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); C07C 229/42 (2013.01); C07C 233/81 (2013.01); C07C 235/38 (2013.01); C07C 235/56 (2013.01); C07C 255/57 (2013.01); C07C 255/58 (2013.01); C07C 275/30 (2013.01); C07C 275/42 (2013.01); C07D 205/04 (2013.01); C07D 207/08 (2013.01); C07D 207/12 (2013.01); C07D 211/08 (2013.01); C07D 211/10 (2013.01); C07D 211/14 (2013.01); C07D 239/34 (2013.01); C07D 239/47 (2013.01); C07D 265/30 (2013.01); C07D 265/36 (2013.01); C07D 277/64 (2013.01); C07D 295/155 (2013.01); C07D 307/22 (2013.01); C07D 309/04 (2013.01); C07D 309/14 (2013.01); C07D 317/46 (2013.01); C07D 335/02 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 407/12 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 471/08 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01);
Abstract

There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

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