The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 03, 2019

Filed:

Mar. 23, 2017
Applicants:

Shandong Xinhua Pharmaceutical Co., Ltd., Zibo, CN;

Shenyang Pharmaceutical University, Shenyang, CN;

Inventors:

Guoliang Chen, Shenyang, CN;

Zhonghui Zheng, Zibo, CN;

Libo Zou, Shenyang, CN;

Daiming Zhang, Zibo, CN;

Chunling Yuan, Shenyang, CN;

Fulong Ren, Zibo, CN;

Xuefei Bao, Shenyang, CN;

Jinheng Gao, Shenyang, CN;

Linbo Zhou, Shenyang, CN;

Wuhong Fang, Shenyang, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 275/38 (2006.01); C07C 2/86 (2006.01); C07C 201/08 (2006.01); C07C 209/36 (2006.01); C07C 231/02 (2006.01); C07C 269/04 (2006.01); C07C 271/28 (2006.01); C07C 273/18 (2006.01); C07C 303/38 (2006.01); C07C 311/48 (2006.01); C07D 211/62 (2006.01); C07D 295/195 (2006.01); A61K 31/167 (2006.01); C07C 259/10 (2006.01); C07C 233/65 (2006.01); C07C 233/80 (2006.01);
U.S. Cl.
CPC ...
C07C 275/38 (2013.01); A61K 31/167 (2013.01); C07C 2/861 (2013.01); C07C 201/08 (2013.01); C07C 209/36 (2013.01); C07C 231/02 (2013.01); C07C 233/65 (2013.01); C07C 233/80 (2013.01); C07C 259/10 (2013.01); C07C 269/04 (2013.01); C07C 271/28 (2013.01); C07C 273/1809 (2013.01); C07C 303/38 (2013.01); C07C 311/48 (2013.01); C07D 211/62 (2013.01); C07D 295/195 (2013.01); C07C 2603/22 (2017.05); C07C 2603/24 (2017.05);
Abstract

An octahydroanthracene compound having the structure shown in formula (I) and (II), preparation method and application thereof are disclosed. The octahydroanthracene compound has a good therapeutic effect on tumors and neurodegenerative diseases. The preparation of the octahydroanthracene compound is mainly carried out by using benzene as a starting material, and being subjected to Friedel-Crafts reaction, nitration, reduction, (sulfo-) amide formation, reduction, urea formation or amide formation, thus obtaining a target compound.


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