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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10399927 B1

PDFFull Text
Date of Patent:
Sep. 03, 2019

Filed:

Feb. 29, 2016

Method for preparing long-chain compound

Applicant:

Hybio Pharmaceutical Co., Ltd., Shenzhen, CN;

Inventors:

Youjin Chen, Shenzhen, CN;

Pengcheng Mi, Shenzhen, CN;

Anjin Tao, Shenzhen, CN;

Jiancheng Yuan, Shenzhen, CN;

Assignee:

HYBIO PHARMACEUTICAL CO., LTD., Shenzhen, CN;

Attorney:

Gokalp Bayramoglu

Primary Examiner:

Sikarl A Witherspoon

Int. Cl.
CPC ...
C07C 231/02 (2006.01); B01J 31/00 (2006.01); C07C 231/14 (2006.01); C07C 269/06 (2006.01); C07C 231/12 (2006.01); B01J 31/02 (2006.01); C07C 237/22 (2006.01); C07B 41/12 (2006.01); C07B 43/06 (2006.01); C07C 235/08 (2006.01);
U.S. Cl.
CPC ...
C07C 231/14 (2013.01); B01J 31/0247 (2013.01); C07C 231/02 (2013.01); C07C 231/12 (2013.01); C07C 237/22 (2013.01); C07C 269/06 (2013.01); B01J 2231/49 (2013.01); C07B 41/12 (2013.01); C07B 43/06 (2013.01); C07B 2200/07 (2013.01); C07C 235/08 (2013.01); Y02P 20/55 (2015.11);
Abstract

The present invention relates to a preparation method of a long-chain compound, which includes the following steps: (1) carrying out condensation reaction on H—Rand RN-Glu(OR)—OR, wherein, Ris a carboxyl protecting group, Ris a carboxyl activating group, and Ris an amino protecting group; obtaining a compound of formula II; (2) removing carboxyl protecting group Rand amino protecting group Rof the compound shown in formula II to obtain a compound of formula III; (3) carrying out condensation reaction on the compound shown in formula III and to obtain a compound shown in formula I. The method reduces the time of deprotection, and all the reactions can be carried out in a solvent with low boiling point. The post-processing requires only simple washing and recrystallization to obtain the product with higher purity, so the method is suitable for large-scale production.

Find Patent Forward Citations

Chen, Youjin. (2019). Method for preparing long-chain compound (U.S. Patent No. 10399927). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10399927

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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