The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 03, 2019

Filed:

Mar. 07, 2014
Applicant:

Biogen MA Inc., Cambridge, MA (US);

Inventor:

Jianhua Chao, Cambridge, MA (US);

Assignee:

Biogen MA Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/22 (2006.01); C07C 69/60 (2006.01); C07C 69/533 (2006.01); A61K 31/225 (2006.01); A61K 31/235 (2006.01); A61K 31/24 (2006.01); A61K 31/5375 (2006.01); A61K 45/06 (2006.01); C07C 69/76 (2006.01); C07C 229/36 (2006.01); C07D 295/145 (2006.01); C07B 59/00 (2006.01);
U.S. Cl.
CPC ...
C07C 69/60 (2013.01); A61K 31/225 (2013.01); A61K 31/235 (2013.01); A61K 31/24 (2013.01); A61K 31/5375 (2013.01); A61K 45/06 (2013.01); C07B 59/001 (2013.01); C07C 69/533 (2013.01); C07C 69/76 (2013.01); C07C 229/36 (2013.01); C07D 295/145 (2013.01);
Abstract

Provided herein are deuterium substituted fumarate derivatives and pharmaceutical compositions comprising deuterium substituted fumarate derivatives. Also provided is a method of treating, prophylaxis, or amelioration of a disease, comprising administering to a subject in need of treatment for the disease an effective amount of a deuterium substituted fumarate derivative or a pharmaceutical composition comprising a deuterium substituted fumarate derivative. In one embodiment, the method is a neurodegenerative disease, such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, or Alzheimer's disease.


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