The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2019
Filed:
Sep. 23, 2016
Applicant:
University Health Network, Toronto, CA;
Inventors:
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 25/14 (2006.01); A61K 49/00 (2006.01); C07K 14/47 (2006.01); A61K 38/17 (2006.01); A61K 39/395 (2006.01); A61P 21/00 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1709 (2013.01); A61K 38/179 (2013.01); A61K 39/395 (2013.01); A61K 49/00 (2013.01); A61P 21/00 (2018.01); A61P 25/14 (2018.01); A61P 25/28 (2018.01); C07K 14/47 (2013.01);
Abstract
Disclosed herein are methods and compositions for increasing and decreasing the permeability of the blood brain barrier for the treatment of diseases and conditions and to facilitate the delivery of agents to the brain, as well as methods and compositions for promoting re-myelination and preventing de-myelination. Compositions include RGMa, soluble RGMa, and functional fragments and variants thereof, RGMc, soluble RGMc, and functional fragments and variants thereof, and Neogenin peptides including 4Ig.