The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 03, 2019

Filed:

Dec. 10, 2015
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Laura Ensign, Towson, MD (US);

Richard Cone, Baltimore, MD (US);

Justin Hanes, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/747 (2015.01); A61K 9/00 (2006.01); A61K 9/19 (2006.01);
U.S. Cl.
CPC ...
A61K 35/747 (2013.01); A61K 9/00 (2013.01); A61K 9/0034 (2013.01); A61K 9/0095 (2013.01); A61K 9/19 (2013.01);
Abstract

Methods and materials for treating bacterial vaginosis ('BV') are provided. Cervicovaginal secretions ('CVS') from a woman with-dominated (>50%) vaginal microbiota is transplanted to women with BV as a method for restoring beneficial vaginal microbial communities and/or increasing resistance to sexually transmitted disease. Efficacy can be enhanced, or the properties of the endogenous CVS improved, through administration of an acidifying agent such as lactic acid. The examples demonstrate the role of healthy CVS in disease resistance, and the effect of pH on CVS properties. The examples also describe the collection and transplantation of healthy beneficial CVS into women at risk for, or after treatment for, BV.


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