The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 03, 2019
Filed:
Feb. 19, 2018
Vanderbilt University, Nashville, TN (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Lawrence J. Marnett, Nashville, TN (US);
Andy J. Liedtke, Nashville, TN (US);
Trevor M. Penning, Springfield, PA (US);
Adegoke O. Adeniji, Drexel Hill, PA (US);
Michael C. Byrns, Philadelphia, PA (US);
Vanderbilt University, Nashville, TN (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.