The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2019
Filed:
Feb. 17, 2011
Pingbo Zhang, Ellicott City, MD (US);
Jennifer E. Van Eyk, Baltimore, MD (US);
Anne M. Murphy, Towson, MD (US);
Ger Stienen, Abcoude, NL;
Jolanda Van Der Velden, Amsterdam, NL;
Viola Kooij, Alphen, NL;
Pingbo Zhang, Ellicott City, MD (US);
Jennifer E. Van Eyk, Baltimore, MD (US);
Anne M. Murphy, Towson, MD (US);
Ger Stienen, Abcoude, NL;
Jolanda van der Velden, Amsterdam, NL;
Viola Kooij, Alphen, NL;
CEDARS-SINAI MEDICAL CENTER, Los Angeles, CA (US);
VU-VUMC IP MANAGEMENT BV, Amsterdam, NL;
Abstract
This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.