The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 27, 2019

Filed:

Oct. 26, 2015
Applicant:

Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E. V., Munich, DE;

Inventors:

Heiko Zimmermann, Waldbrunn, DE;

Frank Stracke, Saarbruecken, DE;

Ronan Le Harzic, Woustviller, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/49 (2006.01); G01N 21/47 (2006.01); G01P 13/00 (2006.01); G01N 21/21 (2006.01);
U.S. Cl.
CPC ...
G01N 21/4788 (2013.01); G01N 21/21 (2013.01); G01N 21/49 (2013.01); G01N 2021/479 (2013.01); G01P 13/00 (2013.01);
Abstract

The invention relates to a method and a device for the optical in vitro detection of a movement in a biological sample and/or for the optical in vitro detection of a movement of a component of the biological sample. The method has the following step: (a) providing an optical wide-field illumination device for illuminating the sample, said device being designed to illuminate the entire sample, and a detector () for detecting radiation () coming from the sample. The detector () has a detection surface () which is divided into multiple detection regions (). The detector is additionally designed to derive (S) detection signals () of individual detection regions () with respect to time, subsequently rectify (S) the signals, preferably by generating an absolute value or squaring, and summing or averaging (S) the derived and rectified detection signals of all of the detection regions and then providing same as an output signal (). The method further has the steps of illuminating the sample using the wide-field illumination device and detecting a movement in the biological sample on the basis of the output signal () of the detector ().


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