The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2019
Filed:
Dec. 04, 2014
Menarini Silicon Biosystems S.p.a., Castel Maggiore, IT;
Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v., München, DE;
Christoph Andreas Klein, Regensburg, DE;
Bernhard Michael Polzer, Munich, DE;
Nicolò Manaresi, Bologna, IT;
Menarini Silicon Biosystems S.p.A., Castel Maggiore, IT;
Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V., München, DE;
Abstract
A method for determining the integrity of the genome of a sample and/or the quality of a library of DNA sequences obtained by deterministic restriction site whole genome amplification can include (a) amplifying the library of DNA sequences to produce first, second, and third PCR products each of a different size from 50 bp to 1000 bp, by PCR using at least one first primer pair, one second primer pair and one third primer pair, the primer pairs each hybridizing to a DNA sequence of the library having a length from 1000 bp to 5000 bp and corresponding to a sequence of the genome located respectively on a first, second and third chromosome arm; (b) detecting the first, second and third PCR products; (c) correlating the presence of the first, second and third PCR products with the integrity of the genome of the sample and/or the quality of the library.