The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2019
Filed:
Feb. 14, 2012
John Fraser Wright, Princeton, NJ (US);
Olga Zelenaia, Ardmore, PA (US);
Bernd Hauck, Hamilton, NJ (US);
Federico Mingozzi, Paris, FR;
Katherine A. High, Merion Station, PA (US);
John Fraser Wright, Princeton, NJ (US);
Olga Zelenaia, Ardmore, PA (US);
Bernd Hauck, Hamilton, NJ (US);
Federico Mingozzi, Paris, FR;
Katherine A. High, Merion Station, PA (US);
THE CHILDREN'S HOSPITAL OF PHILADELPHIA, Philadelphia, PA (US);
Abstract
This application relates to the fields of gene therapy and molecular biology. In accordance with the present invention, an adeno-associated virus (AAV) vector comprising an altered capsid protein is provided. More specifically, this invention provides adeno-associated viral vectors comprising protein capsid variants which accelerate vector breakdown and clearance, thereby reducing undesirable immune responses.