The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2019
Filed:
Mar. 25, 2016
Applicant:
Keio University, Tokyo, JP;
Inventors:
Masatoshi Hirayama, Tokyo, JP;
Minoru Ko, Tokyo, JP;
Assignee:
KEIO UNIVERSITY, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07K 14/00 (2006.01); C07H 21/04 (2006.01); C12N 5/00 (2006.01); C12N 15/63 (2006.01); C12N 5/079 (2010.01); C12N 5/10 (2006.01); C12N 5/074 (2010.01); C12N 5/16 (2006.01); C12N 15/85 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0621 (2013.01); C07K 14/4702 (2013.01); C07K 14/4703 (2013.01); C12N 5/0607 (2013.01); C12N 5/10 (2013.01); C12N 5/16 (2013.01); C12N 15/85 (2013.01); C07H 21/04 (2013.01); C12N 15/63 (2013.01); C12N 2501/01 (2013.01); C12N 2501/11 (2013.01); C12N 2501/117 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2510/00 (2013.01);
Abstract
Provided is a method of producing a lacrimal gland epithelial cell from a pluripotent stem cell, a lacrimal gland epithelial cell produced by the method, and a reagent kit for inducing differentiation from a pluripotent stem cell into a lacrimal gland epithelial cell. A method of producing a lacrimal gland epithelial cell includes the following step A: Step A: a step including increasing expression of Pax6 gene in a pluripotent stem cell or transfecting PAX6 protein thereinto, and increasing expression of Foxc1 gene or Foxp1 gene in the pluripotent stem cell or transfecting FOXC1 protein or FOXP1 protein thereinto.