The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2019
Filed:
Aug. 15, 2016
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Gordon Keller, Toronto, CA;
Valerie Kouskoff, Manchester, GB;
Atsushi Kubo, Nara, JP;
Hans J. Fehling, Ulm, DE;
Assignee:
ICAHN School of Medicine at Mount Sinai, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 5/0735 (2010.01); G01N 33/50 (2006.01); C12N 5/073 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0606 (2013.01); C12N 5/0603 (2013.01); G01N 33/5073 (2013.01); C12N 2500/90 (2013.01); C12N 2501/16 (2013.01); C12N 2501/415 (2013.01); C12N 2506/02 (2013.01);
Abstract
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. In accordance with the present invention, a selectable marker gene has been recombinantly targeted to the brachyury locus to allow the isolation and characterization of cell populations that comprise brachyury positive mesendoderm and mesoderm cells. The cell populations of the invention are useful for generating cells for cell replacement therapy.