The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2019
Filed:
Dec. 23, 2015
Applicant:
Proteostasis Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Cecilia M. Bastos, South Grafton, MA (US);
Benito Munoz, Newtonville, MA (US);
Bradley Tait, Malden, MA (US);
Assignee:
Proteostasis Therapeutics, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/06 (2006.01); G01N 33/50 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); C07D 277/56 (2006.01); C07D 417/12 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
C07D 417/12 (2013.01); A61K 31/426 (2013.01); A61K 31/427 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 277/56 (2013.01); G01N 33/502 (2013.01); G01N 33/5044 (2013.01);
Abstract
The present disclosure is based, in part, on the discovery that disclosed compounds such as those having Formula (IIIa), (III), or (IV) can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells.