The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 27, 2019

Filed:

May. 19, 2016
Applicants:

Sanwa Kagaku Kenkyusho Co., Ltd., Nagoya-shi, Aichi, JP;

Ube Industries, Ltd., Ube-shi, Yamaguchi, JP;

Inventors:

Ryo Iwamura, Ube, JP;

Yasunori Tsuzaki, Ube, JP;

Hiroyuki Setoguchi, Ube, JP;

Hiroto Akaza, Ube, JP;

Yasuhito Yamamoto, Ube, JP;

Akira Takama, Ube, JP;

Yuka Kuno, Nagoya, JP;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 209/52 (2006.01); A61K 31/403 (2006.01); A61P 25/36 (2006.01);
U.S. Cl.
CPC ...
C07D 209/52 (2013.01); A61K 31/403 (2013.01); A61P 25/36 (2018.01); C07B 2200/13 (2013.01);
Abstract

Disclosed herein are a crystal comprising a compound, which has μ-opioid receptor antagonistic action, few side effects, and high safety, and having high purity and excellent physical properties (stability, solubility, etc.), and a method for producing the crystal. The crystal is a crystal of a salt comprising: a compound represented by a formula (I) [wherein Ris a hydrogen atom or a halogen atom, and Ris a group selected from the group consisting of and an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, and oxalic acid, or a hydrate thereof.


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