The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 27, 2019
Filed:
Sep. 26, 2018
Pulse Biosciences, Inc., Hayward, CA (US);
Richard Lee Nuccitelli, Millbrae, CA (US);
Pamela S. Nuccitelli, Millbrae, CA (US);
Joanne Lum, San Francisco, CA (US);
Kaying Lui, Millbrae, CA (US);
Brian G. Athos, San Francisco, CA (US);
Mark P. Kreis, San Francisco, CA (US);
Zachary R. Mallon, San Francisco, CA (US);
Jon Berridge, Oakland, CA (US);
PULSE BIOSCIENCES, INC., Hayward, CA (US);
Abstract
Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.